4-Methoxyphenol → 4-(4-Methoxyphenoxy)benzaldehyde

HRID 1586091노트

반응식

HRID 1586091 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.Br[C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][CH:12]=1.C(=O)([O-])[O-].[K+].[K+]>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:11]2[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][CH:12]=2)=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 90154-MethoxyphenolHCID 11430Potassium CarbonateHCID 707414-Bromobenzaldehyde

생성물 1

HCID 104895194-(4-Methoxyphenoxy)benzaldehyde수율 85%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A mixture of 4-methoxyphenol (1.0 g, 0.00806 mol), 4-bromobenzaldehyde (1.49 g, 0.00805 mol), CuO (0.64 g, 0.00805 mol), potassium carbonate (1.11 g, 0.00803 mol) in pyridine (100 mL) was refluxed for 60 h. The reaction mixture was filtered into ice/water and the product was extracted with ethyl acetate. The organic layer was washed with water, dried (MgSO4), concentrated and chromatographed with CH2Cl2 to afford 1.56 g (85%) of 4-(4-methoxyphenoxy)benzaldehyde.

후처리

  1. temperaturewas refluxed for 60 h
  2. filtrationThe reaction mixture was filtered into ice/water
  3. extractionthe product was extracted with ethyl acetate
  4. washThe organic layer was washed with water
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated
  7. customchromatographed with CH2Cl2

출처 및 근거

ORD 기록
ord-5241f8d49ba34ccbafa6ce360080a7f6
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05942532

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