Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → N-(1-ethylpyrazol-5-yl)-4-nitroanthranilic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 2-Chloro-4-nitrobenzoic acid | HCID 7448 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Ethyl-1H-pyrazol-5-amine | HCID 337310 | — |
| 촉매 | Cupric acetate | HCID 8895 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-(1-ethylpyrazol-5-yl)-4-nitroanthranilic acid | HCID 21217705 | 63.3% |
반응 단계
A mixture of 2-chloro-4-nitrobenzoic acid (4.03 g, 0.02 mol), 5-amino-1-ethylpyrazole (2.22 g, 0.02 mol), DMF (25 ml), K2CO3 (2.76 g, 0.02 mol) and Cu(OAc)2. H2O (0.5 g) is refluxed for 24 hours. The reaction mixture is cooled to room temperature, poured into ice water and then acidified with acetic acid to a pH of 5. A solid forms which is collected by filtration and dried to afford 3.5 g (63%) of N-(1-ethylpyrazol-5-yl)-4-nitroanthranilic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05942520 |
| 출처 데이터셋 | uspto-grants-1999_08 |
| ORD ID | ord-1d6cc3cdea1e4719818b6de8e5662f08 |
| 출처 메모 | uspto-grants-1999_08 |