Ammonium Hydroxide → 1-ethyl-4-chloro-7-nitro-1H-pyrazolo[3,4-b]quinoline

참여 물질

역할	이름	HCID	투입량
반응물	Ammonium Hydroxide	HCID 14923	—
반응물	Phosphorus oxychloride	HCID 24813	—
반응물	N-(1-ethylpyrazol-5-yl)-4-nitroanthranilic acid	HCID 21217705	—
생성물	1-ethyl-4-chloro-7-nitro-1H-pyrazolo[3,4-b]quinoline	HCID 54338796	82%

반응 단계

A mixture of N-(1-ethylpyrazol-5-yl)-4-nitroanthranilic acid (3.4 g, 12.32 mmol) and POCl3 (20 ml) is refluxed for 8 hours. The reaction mixture is poured into ice waterl, neutralized with concentrated NH4OH, and the resulting solid is collected by filtration,washed with water and dried to afford 2.8 g (82%) of 1-ethyl-4-chloro-7-nitro-1H-pyrazolo[3,4-b]quinoline.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05942520
출처 데이터셋	uspto-grants-1999_08
ORD ID	ord-ebf142312dc747bd91960e42e40c6e6d
출처 메모	uspto-grants-1999_08