Ammonia → (2S,3S)-2 ethyl-3-hydroxybutyramide

HRID 1586299노트

반응식

HRID 1586299 반응식
[CH2:1]([C@@H:3]([C@@H:9]([OH:11])[CH3:10])[C:4](OCC)=[O:5])[CH3:2].[NH3:12]>C(O)C>[CH2:1]([C@@H:3]([C@@H:9]([OH:11])[CH3:10])[C:4]([NH2:12])=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 13215287(2S,3S)-Ethyl 2 ethyl-3-hydroxybutyrate

생성물 1

HCID 11829477(2S,3S)-2 ethyl-3-hydroxybutyramide수율 85.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

(2S,3S)-Ethyl 2 ethyl-3-hydroxybutyrate (1 gram) is dissolved in 5 ml of absolute ethanol followed by the addition of 0.5 gram of gaseous ammonia. The solution is kept in a stoppered flask, and the progress of the reaction is followed by thin layer chromatography. After the reaction is judged complete, the ethanol is evaporated and the resulting residue redissolved in ethyl acetate. Ammonia is removed by extraction with 1% HCl, and the ethyl acetate solution is dried over MgSO4, filtered, and rotary evaporated to leave 0.7 grams of (2S,3S)-2 ethyl-3-hydroxybutyramide.

후처리

  1. customThe solution is kept in a stoppered flask
  2. customthe ethanol is evaporated
  3. dissolutionthe resulting residue redissolved in ethyl acetate
  4. customAmmonia is removed by extraction with 1% HCl
  5. dry with materialthe ethyl acetate solution is dried over MgSO4
  6. filtrationfiltered
  7. customrotary evaporated

출처 및 근거

ORD 기록
ord-8ad26da8a07a40f5a378a9c9369f7788
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05942644

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