Water → 2-Chloro-4-methyl-6-phenyl-1,3,5-triazine

HRID 1586400노트

반응식

HRID 1586400 반응식
[Cl:1][C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1.[CH3:15][Mg]Br.O1CCCC1.O>O1CCCC1>[Cl:1][C:2]1[N:7]=[C:6]([CH3:15])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 155492,4-Dichloro-6-phenyl-1,3,5-triazineHCID 178420675HCID 178420675, 화합물

생성물 1

HCID 356892-Chloro-4-methyl-6-phenyl-1,3,5-triazine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In 85 ml of dry tetrahydrofuran was dissolved 17 g of 2,4-dichloro-6-phenyl-1,3,5-triazine. To this solution on an ice-water bath was added 135 ml of 1M methylmagnesium bromide-tetrahydrofuran dropwise over about 30 minutes. After completion of dropwise addition, the mixture was stirred at room temperature for 2 hours. This reaction mixture was poured into iced water and extracted with ethyl acetate. The extract was washed with water, dried over MgSO4, and concentrated. The residue was purified with silica gel column chromatography to provide 3.6 g of the title compound as white crystals.

후처리

  1. additionAfter completion of dropwise addition
  2. extractionextracted with ethyl acetate
  3. washThe extract was washed with water
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated
  6. customThe residue was purified with silica gel column chromatography

출처 및 근거

ORD 기록
ord-c269438ca97642baaed20ba7e5f021da
출처 데이터셋
uspto-grants-1999_08
특허 번호
US05945426

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