N-docosahexaenoyl (4-hydroxyphenyl)-glycine → N-(4-Hydroxyphenyl)glycine

반응식

C([N:22]([C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=1)[CH2:23][C:24]([OH:26])=[O:25])(=O)C=CC=CC=CC=CC=CCCCCCCCCC.C(N(C1C=CC(O)=CC=1)CC(O)=O)(=O)C=CC=CC=CC=CC=CC=CCCCCCCCCC>>[OH:33][C:30]1[CH:31]=[CH:32][C:27]([NH:22][CH2:23][C:24]([OH:26])=[O:25])=[CH:28][CH:29]=1

참가 물질

반응물 2

HCID 53923752N-docosahexaenoyl (4-hydroxyphenyl)-glycine

HCID 54079310N-eicosapentaenoyl (4-hydroxyphenyl)-glycine

생성물 1

HCID 67149N-(4-Hydroxyphenyl)glycine

실험 절차

The same procedure as in Example 5 but EPA-Cl was replaced by 4.2 g (0.012 mole) of the mixture of polyunsaturated fatty acyl chlorides as prepared in Example 4. Yield of the mixed product was about 88 percent, containing N-eicosapentaenoyl (4-hydroxyphenyl)-glycine and N-docosahexaenoyl (4-hydroxyphenyl)-glycine as the main components.

후처리

customas prepared in Example 4

출처 및 근거

ORD 기록: ord-180f66a0ac3f4abc9d685a80c62a8443
출처 데이터셋: uspto-grants-1993_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05216023

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