4-Fluorobenzoyl chloride → 2-(4-Fluorophenyl)-6-hydroxybenzothiazole

HRID 1586885노트

반응식

HRID 1586885 반응식
NC1C=CC(OC)=CC=1S.FC1C=CC(C(Cl)=O)=CC=1.[F:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[S:29][C:30]3[CH:36]=[C:35]([O:37]C)[CH:34]=[CH:33][C:31]=3[N:32]=2)=[CH:24][CH:23]=1>>[F:21][C:22]1[CH:23]=[CH:24][C:25]([C:28]2[S:29][C:30]3[CH:36]=[C:35]([OH:37])[CH:34]=[CH:33][C:31]=3[N:32]=2)=[CH:26][CH:27]=1

참가 물질

4

반응물 3

HCID 678794-Fluorobenzoyl chlorideHCID 2355092-Amino-5-methoxybenzene-1-thiolHCID 121799872-(4-Fluorophenyl)-6-methoxy-1,3-benzothiazole

생성물 1

HCID 167341662-(4-Fluorophenyl)-6-hydroxybenzothiazole

실험 절차

The procedure set out in Example 7 is repeated using 2-amino-5-methoxybenzenethiol and 4-fluorobenzoyl chloride. The reaction yields a mixture of the title compound and 2-(4-fluorophenyl)-6-methoxybenzothiazole. The mixture is treated with excess boiling 48 percent HBr for one hour to convert the latter product to the title compound. The solution is filtered and the precipitate is recrystallized from ethanol and water. The overall yield is 80.3 percent based on the initial amount of benzenethiol. A recrystallized product melts at about 221° C.-223° C.

후처리

  1. customThe reaction yields

출처 및 근거

ORD 기록
ord-51a11d9d083849aa852cccff0eeedb65
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05216110

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