Sodium Carbonate → 4,4'-Bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyrimidine

HRID 1586936노트

반응식

HRID 1586936 반응식
Cl[CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[N:14]=[C:13]([CH2:15]Cl)[CH:12]=[CH:11][N:10]=2)[N:4]=1.[NH:17]([CH2:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20].[C:34](=[O:37])([O-:36])[O-].[Na+].[Na+]>C(#N)C>[C:30]([O:29][C:27]([CH2:26][N:17]([CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[N:14]=[C:13]([CH2:15][N:17]([CH2:18][C:19]([O:21][C:22]([CH3:25])([CH3:23])[CH3:24])=[O:20])[CH2:26][C:34]([O:36][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:37])[CH:12]=[CH:11][N:10]=2)[N:4]=1)[CH2:18][C:19]([O:21][C:22]([CH3:24])([CH3:25])[CH3:23])=[O:20])=[O:28])([CH3:33])([CH3:32])[CH3:31]

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 4393691DI-T-Butyl iminodiacetateHCID 197601294,4'-Bis(chloromethyl)-2,2'-bipyrimidine

생성물 1

HCID 197601264,4'-Bis(N,N-bis(t-butoxycarbonylmethyl)aminomethyl)-2,2'-bipyrimidine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

4,4'-Bis(chloromethyl)-2,2'-bipyrimidine (18.0 mg, 0.0793 mmoles), di-t-butyl iminodiacetate (76.3 mg, 0.31 mmoles), sodium carbonate (210 mg) and acetonitrile (3 ml) were refluxed overnight. The mixture was filtered, the solvent was evaporated and the product was purified by flash chromatography (silica, 0-5% methanol/chloroform).

후처리

  1. filtrationThe mixture was filtered
  2. customthe solvent was evaporated
  3. customthe product was purified by flash chromatography (silica, 0-5% methanol/chloroform)

출처 및 근거

ORD 기록
ord-3ae7fa321c324cd4a1d2146bfa9d575b
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05216134

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