Cholic Acid → Apocholic acid

HRID 1587032노트

반응식

HRID 1587032 반응식
[CH3:1][C@@H:2]([C@@H:8]1[C@@:12]2([CH3:29])[C@@H:13]([OH:28])[CH2:14][C@@H:15]3[C@@:20]4([CH3:26])[CH2:21][CH2:22][C@@H:23]([OH:25])[CH2:24][C@H:19]4[CH2:18][C@@H:17](O)[C@H:16]3[C@@H:11]2[CH2:10][CH2:9]1)[CH2:3][CH2:4][C:5]([OH:7])=[O:6]>CC(C)=O.[Cl-].[Zn+2].[Cl-]>[OH:25][C@@H:23]1[CH2:22][CH2:21][C@@:20]2([CH3:26])[C@H:19]([CH2:18][CH2:17][C:16]3[C@@H:15]2[CH2:14][C@H:13]([OH:28])[C@@:12]2([CH3:29])[C:11]=3[CH2:10][CH2:9][C@@H:8]2[C@H:2]([CH3:1])[CH2:3][CH2:4][C:5]([OH:7])=[O:6])[CH2:24]1

참가 물질

4

반응물 1

HCID 221493Cholic Acid

생성물 1

HCID 101818Apocholic acid

시약·촉매·용매 2

HCID 3007855Zincchloride촉매HCID 180Acetone용매

반응 조건

온도
110 °C

실험 절차

A mixture of cholic acid (11.4 g) and zinc chloride (13 g) in acetone (50 ml) is heated so as to distil off solvent, then heated at an external temperature of 110° C. for about 1.5 hours. The mixture is poured into water, extracted with ether and the organic solution dried over magnesium sulfate, dried, filtered, and concentrated in vacuo. The crude is purified by flash chromatography to give the desired product.

후처리

  1. temperatureis heated so as
  2. customto distil off solvent
  3. additionThe mixture is poured into water
  4. extractionextracted with ether
  5. dry with materialthe organic solution dried over magnesium sulfate
  6. customdried
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo
  9. customThe crude is purified by flash chromatography

출처 및 근거

ORD 기록
ord-ece4ca440c0644d1b45c6272a01696a0
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05216015

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