Sulfuric Acid → HCID 10815838, 화합물

반응식

[CH2:1]([O:3][C:4]1[CH:12]=[C:11]([CH2:13][C:14]#[N:15])[CH:10]=[CH:9][C:5]=1[C:6]([O-:8])=[O:7])[CH3:2].[CH:16]1([CH2:22][CH:23](O)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[N:30]2[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1.S(=O)(=O)(O)[OH:38].Cl[C:43]1[CH:48]=CC=CC=1Cl>>[CH2:1]([O:3][C:4]1[CH:12]=[C:11]([CH2:13][C:14]([NH:15][CH:23]([CH2:22][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[N:30]2[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)=[O:38])[CH:10]=[CH:9][C:5]=1[C:6]([O:8][CH2:48][CH3:43])=[O:7])[CH3:2]

참가 물질

반응물 4

HCID 1118Sulfuric Acid

HCID 72391,2-Dichlorobenzene2회

HCID 21261766HCID 21261766, 화합물

HCID 54424526HCID 54424526, 화합물

생성물 1

HCID 10815838HCID 10815838, 화합물

실험 절차

At 23°-25° C., a solution of 2-ethoxy-4-cyanomethyl-benzoate (2.35 g, 10 mmol) and α-cyclohexylmethyl-2-piperidino-benzyl alcohol (2.88 g, 10 mmol) in o-dichlorobenzene (15 ml) is added dropwise to a mixture of concentrated sulphuric acid (15 ml) and o-dichlorobenzene (15 ml). The mixture is stirred for 2 hours at ambient temperature. The o-dichlorobenzene phase is then separated off and the residue is added to ice. After being made alkaline with soda solution, it is extracted with chloroform. The extracts are dried over sodium sulphate and concentrated by evaporation. The residue is purified by column chromatography on silica gel (toluene/acetone=10/1).