p-Toluidine → Benzoic acid, 2-[[[(4-methylphenyl)amino]acetyl]amino]-

HRID 1587415노트

반응식

HRID 1587415 반응식
Cl[CH2:2][C:3]([NH:5][C:6]1[C:7](=[CH:11][CH:12]=[CH:13][CH:14]=1)[C:8]([OH:10])=[O:9])=[O:4].[NH2:15][C:16]1[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=1>CN(C)C=O>[CH3:22][C:19]1[CH:20]=[CH:21][C:16]([NH:15][CH2:2][C:3]([NH:5][C:6]2[C:7](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:8]([OH:10])=[O:9])=[O:4])=[CH:17][CH:18]=1

참가 물질

4

반응물 2

HCID 7813p-ToluidineHCID 919916HCID 919916, 화합물

생성물 1

HCID 10493293Benzoic acid, 2-[[[(4-methylphenyl)amino]acetyl]amino]-수율 182.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
90 °C

실험 절차

N(chloroacetyl)anthranilic acid 3.2 g (0.02 mol) and p-toluidine 3.4 g (0.005 mol) were dissolved in 4 ml of dimethylformamide and heated at 90° C. for 3 hours. The reaction solution was poured into ice water and deposited crystals were collected by filtration. These crystals were washed with ether and recrystallized from ethanol to obtain N-[(4-methylphenylamino)acetyl]anthranilic acid 2.6 g (yield: 70%).

후처리

  1. filtrationwere collected by filtration
  2. washThese crystals were washed with ether
  3. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-61fdc2c96d8a46b6b9de31e9a02cc708
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05217961

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