Benzene → 2H-Chromen-2-ol

HRID 1587425

반응식

HRID 1587425 반응식
[OH2:1].[C:2]1([CH3:12])[CH:7]=[CH:6][C:5](S(O)(=O)=O)=[CH:4][CH:3]=1.[OH2:13].[CH:14]1[CH:19]=CC=CC=1>>[O:1]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[CH:12]=[CH:14][CH:19]1[OH:13]

참가 물질

4

반응물 3

HCID 241Benzene2회HCID 962WaterHCID 521998p-Toluenesulfonic acid monohydrate

생성물 1

HCID 136137092H-Chromen-2-ol

실험 절차

The above oil is very oxidatively unstable and was immediately dissolved in about 200 ml of benzene containing p-toluenesulfonic acid monohydrate (500 mg, 2.63 mmole). The benzene solution was heated for about 2 hours under reflux with water removal facilitated by a Dean-Stark apparatus. The cooled benzene mixture was washed with aqueous NaHCO3, dried (brine, MgSO4) and stripped in vacuo to give crude [12a] isolated as a dark gum (4.86 g).

후처리

  1. washThe cooled benzene mixture was washed with aqueous NaHCO3
  2. dry with materialdried (brine, MgSO4)

출처 및 근거

ORD 기록
ord-da9e4cde35a941f0b795ef77e67a6833
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05217992

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