참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Aniline | HCID 6115 | — |
| 반응물 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | Benzenesulfonamide, 4-methyl-N-phenyl- | HCID 2456 | — |
반응 단계
Dissolve aniline (930 mg, 10 mmol) in anhydrous pyridine (25 mL) and cool to 5° C. Add, by dropwise addition, p-toluenesulfonyl chloride (2.1 g, 11 mmol) and stir overnight. Partition between water and ethyl acetate and separate the organic phase. Wash the organic phase with cold 1N hydrochloric acid, saturated sodium hydrogen carbonate and brine. Dry (MgSO4) and evaporate the solvent in vacuo to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05217964 |
|---|
| 출처 데이터셋 | uspto-grants-1993_06 |
|---|
| ORD ID | ord-17afee4eb84643fa9f4983b8a056dfdb |
|---|
| 출처 메모 | uspto-grants-1993_06 |
|---|
