Potassium Carbonate → 1-(2-Chloropyridin-5-ylmethyl)-2-nitroimino-3-(2-propylphenyliminomethyl)imidazolidine

HRID 1587731노트

반응식

HRID 1587731 반응식
[CH2:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]=[CH:11][N:12]1[CH2:16][CH2:15][NH:14][C:13]1=[N:17][N+:18]([O-:20])=[O:19])[CH2:2][CH3:3].[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28]Cl)=[CH:24][N:23]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([CH2:28][N:14]2[CH2:15][CH2:16][N:12]([CH:11]=[N:10][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[CH2:1][CH2:2][CH3:3])[C:13]2=[N:17][N+:18]([O-:20])=[O:19])=[CH:24][N:23]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 1554792-Chloro-5-(chloromethyl)pyridineHCID 1363314791-(2-n-Propylphenyliminomethyl)-nitroiminoimidazolidine

생성물 1

HCID 542035321-(2-Chloropyridin-5-ylmethyl)-2-nitroimino-3-(2-propylphenyliminomethyl)imidazolidine수율 30.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 0.8 g of 1-(2-n-propylphenyliminomethyl)-nitroiminoimidazolidine, 0.42 g of 2-chloro-5-chloromethylpyridine, 0.36 g of potassium carbonate and 8 ml of acetonitrile were refluxed under heating conditions for 4 hours. The reaction mixture was evaporated and purified by column chromatography [silica gel, eluent: hexane-ethyl acetate (1:2)] to give 0.32 g of 1-(2-chloropyridin-5-ylmethyl)-2-nitroimino-3-(2-propylphenyliminomethyl)imidazolidine.

후처리

  1. temperaturewere refluxed under heating conditions for 4 hours
  2. customThe reaction mixture was evaporated
  3. custompurified by column chromatography [silica gel, eluent: hexane-ethyl acetate (1:2)]

출처 및 근거

ORD 기록
ord-5ddc29948fe54cecac3aedbfe4a3091c
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05219868

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