4-Hydroxyphenylacetone → HCID 19974251, 화합물

반응식

[OH:1][CH:2]([C:5]1[N:6]=[C:7]([CH3:10])[S:8][CH:9]=1)[CH2:3][NH2:4].[OH:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19](=O)[CH3:20])=[CH:14][CH:13]=1>>[OH:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH:19]([NH:4][CH2:3][CH:2]([OH:1])[C:5]2[N:6]=[C:7]([CH3:10])[S:8][CH:9]=2)[CH3:20])=[CH:14][CH:13]=1

참가 물질

반응물 2

HCID 70192744-Hydroxyphenylacetone

HCID 167684962-Amino-1-(2-methyl-1,3-thiazol-4-yl)ethanol

생성물 1

HCID 19974251HCID 19974251, 화합물

실험 절차

Prepared by analogy to Example 13 by reaction of 2-hydroxy-2-(2-methyl-thiazol-4-yl)ethanamine with 4-hydroxyphenyl-propan-2-one followed by purification of the base on a silica gel column using chloroform/methanol/ammonia=9:1:1 as eluant.

후처리

customfollowed by purification of the base on a silica gel column

출처 및 근거

ORD 기록: ord-1ff79aaa5d714b4ea98be4596d4a024d
출처 데이터셋: uspto-grants-1993_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05219852

반응 노트

불러오는 중…