HCID 15932586, 화합물 → HCID 54372859, 화합물

HRID 1588118노트

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HRID 1588118 반응식
[C:1]([NH:4][C@@H:5]1[C@@H:10]([OH:11])[C@H:9]([OH:12])[C@@H:8]([CH2:13][OH:14])[O:7][C@H:6]1[O:15][C@H:16]1[C@@H:31]([OH:32])[C@@H:30]([CH2:33][O:34][C@@H:35]2[O:42][C@H:41]([CH2:43][OH:44])[C@@H:39]([OH:40])[C@H:37]([OH:38])[C@H:36]2[NH:45][C:46](=[O:48])[CH3:47])[O:29][C@@H:18]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])[C@@H:17]1[OH:49])(=[O:3])[CH3:2].C1C(=O)NC(=O)NC=1[C@@H]1O[C@H](COP(OP(O[C@H:73]2[O:78][C@H:77]([CH2:79][OH:80])[C@H:76]([OH:81])[C@H:75]([OH:82])[C@H:74]2[OH:83])(O)=O)(O)=O)[C@@H](O)[C@H]1O>[As](C)(C)(=O)[O-].[Na+].[Cl-].[Mn+2].[Cl-]>[C@@H:18]1([O:12][C@@H:9]2[C@@H:8]([CH2:13][OH:14])[O:7][C@@H:6]([O:15][C@H:16]3[C@@H:31]([OH:32])[C@@H:30]([CH2:33][O:34][C@@H:35]4[O:42][C@H:41]([CH2:43][OH:44])[C@@H:39]([O:40][C@@H:73]5[O:78][C@H:77]([CH2:79][OH:80])[C@H:76]([OH:81])[C@H:75]([OH:82])[C@H:74]5[OH:83])[C@H:37]([OH:38])[C@H:36]4[NH:45][C:46](=[O:48])[CH3:47])[O:29][C@@H:18]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]([O:27][CH3:28])=[O:26])[C@@H:17]3[OH:49])[C@H:5]([NH:4][C:1](=[O:3])[CH3:2])[C@H:10]2[OH:11])[O:29][C@H:30]([CH2:33][OH:34])[C@H:31]([OH:32])[C@H:16]([OH:15])[C@H:17]1[OH:49]

참가 물질

5

반응물 2

HCID 15932586HCID 15932586, 화합물HCID 54584734HCID 54584734, 화합물

생성물 1

HCID 54372859HCID 54372859, 화합물

시약·촉매·용매 2

HCID 10313134Manganese(2+) dichloride촉매HCID 2724247Sodium Cacodylate용매

실험 절차

A solution of compound 19 of Example 19 (85 mg), UDP-galactose, (190 mg), bovine galactosyltransferase (6.25 U) and bovine serum albumin (3 mg) in 30 mM sodium cacodylate buffer (7 mL, pH 7.0) containing manganese chloride (40 umol) was incubated at 37° C. for 22 h. The reaction mixture was diluted to 20 mL and purified as described in Example 21. Yield of the product was 114 mg. The structural identity of titled compound 25 was unambiguously assigned by 1H- and 13C-n.m.r (see Tables 4 and 5, respectively).

후처리

  1. additionThe reaction mixture was diluted to 20 mL
  2. custompurified

출처 및 근거

ORD 기록
ord-0a5c0b049c9d4a96ad88ce34cc641b1e
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05220008

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