Tetrabutylammonium Fluoride → 1-(2-Hydroxyethyl)-2,5-dimethoxy-3,6-bis(methoxymethoxy)benzene

HRID 1588135노트

반응식

HRID 1588135 반응식
[Si]([O:8][CH2:9][CH2:10][C:11]1[C:16]([O:17][CH2:18][O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=[C:13]([O:23][CH2:24][O:25][CH3:26])[C:12]=1[O:27][CH3:28])(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[OH:8][CH2:9][CH2:10][C:11]1[C:16]([O:17][CH2:18][O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=[C:13]([O:23][CH2:24][O:25][CH3:26])[C:12]=1[O:27][CH3:28]

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 197572472-[2,5-Dimethoxy-3,6-bis(methoxymethoxy)phenyl]ethyl tert-butyldimethylsilyl ether

생성물 1

HCID 137145691-(2-Hydroxyethyl)-2,5-dimethoxy-3,6-bis(methoxymethoxy)benzene

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

15.0 Milligrams of 2-[2,5-dimethoxy-3,6-bis(methoxymethoxy)phenyl]ethyl tert-butyldimethylsilyl ether was dissolved in 2 ml of anhydrous tetrahydrofuran, under argon gas stream conditions, 0.1 ml of tetrahydrofuran solution of 1 mole of tetra-n-butylammonium fluoride was added thereto and stirred for 30 minutes, the reaction of removal of the protecting group was completed quantitatively. The solvent was removed by evaporation under reduced pressure, and the residue obtained was treated on a silica gel thin layer chromatography and purified by developing with 30% ethyl acetate-n-hexane to yield 9.0 mg of 1-(2-hydroxyethyl)-2,5-dimethoxy-3,6-bis(methoxymethoxy)benzene.

후처리

  1. additionwas added
  2. customthe reaction of removal of the protecting group
  3. customThe solvent was removed by evaporation under reduced pressure
  4. customthe residue obtained
  5. additionwas treated on a silica gel thin layer chromatography
  6. custompurified

출처 및 근거

ORD 기록
ord-cfbe83558bc4444ba32710253b9d5b76
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05220042

반응 노트

불러오는 중…