Hydrazine → bemoradan

HRID 1588334노트

반응식

HRID 1588334 반응식
[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12](=O)[CH:13]([CH3:18])[CH2:14][C:15](O)=[O:16])=[CH:11][C:5]=2[O:4][CH2:3]1.[NH2:20][NH2:21]>C(O)C>[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]3[CH:13]([CH3:18])[CH2:14][C:15](=[O:16])[NH:20][N:21]=3)=[CH:11][C:5]=2[O:4][CH2:3]1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 11065271HCID 11065271, 화합물

생성물 1

HCID 5362399bemoradan수율 93%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-(3,4-Dihydro-3-oxo-1,4(2H)-benzoxazin-7-yl)-4-oxo-3-methylbutyric acid (31 g, 0.12 moles) was dissolved in ethanol (300 ml) and anhydrous hydrazine (4.7 ml, 0.15 moles) was added. The mixture was heated at reflux overnight. White crystals formed after the mixture was cooled. The crystals were collected by filtration and washed well with ethanol. The solid was dried under vacuum giving 28.5 g (93%) of the titled compound, mp 299°-302° C.

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux overnight
  3. customWhite crystals formed after the mixture
  4. temperaturewas cooled
  5. filtrationThe crystals were collected by filtration
  6. washwashed well with ethanol
  7. customThe solid was dried under vacuum

출처 및 근거

ORD 기록
ord-9ab5686fe7e246cc8b97ed1e68459d7b
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05221742

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