Acetamide, N-[4-(2-quinolinylmethoxy)phenyl]- → 4-(Quinolin-2-ylmethoxy)aniline

HRID 1588430

반응식

HRID 1588430 반응식
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:14]=2)=[CH:7][CH:6]=1)(=O)C>CCO>[N:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:21]=[CH:22][C:13]=1[CH2:12][O:11][C:8]1[CH:9]=[CH:10][C:5]([NH2:4])=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 2747568Acetamide, N-[4-(2-quinolinylmethoxy)phenyl]-

생성물 1

HCID 27475694-(Quinolin-2-ylmethoxy)aniline

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A suspension of N-acetyl-4-(quinolin-2-ylmethoxy)aniline (Step 1, 108.9 g) in 1 L of 95% EtOH containing 10M KOH (120 mL) was heated at reflux under nitrogen in a heating mantle. When the hydrolysis was complete (approx. 36 h), the reaction mixture was cooled and EtOH was partially removed under vacuum. The mixture was then diluted with H2O (200 mL) and the fine off-white crystals were collected and thoroughly rinsed with water. The material, after air-drying, yielded 4-(quinolin-2-ylmethoxy)aniline which was used as such in the next step.

후처리

  1. temperaturewas heated
  2. temperatureat reflux under nitrogen in a heating mantle
  3. custom(approx. 36 h)
  4. temperaturethe reaction mixture was cooled
  5. customEtOH was partially removed under vacuum
  6. additionThe mixture was then diluted with H2O (200 mL)
  7. customthe fine off-white crystals were collected
  8. washthoroughly rinsed with water
  9. customThe material, after air-drying

출처 및 근거

ORD 기록
ord-b73229b782fd443f82bfedca8de43f9a
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05221678

연결된 노트

불러오는 중…