2-Butanamine, 3,3-dimethyl- → N-cyano-N'-(1,2,2-trimethylpropyl)-2-pyridinecarboximidamide

HRID 1588506노트

반응식

HRID 1588506 반응식
[C:1]([N:3]=[C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)OC)#[N:2].[CH3:13][CH:14]([NH2:19])[C:15]([CH3:18])([CH3:17])[CH3:16]>CO>[C:1]([NH:3][C:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)=[N:19][CH:14]([CH3:13])[C:15]([CH3:18])([CH3:17])[CH3:16])#[N:2]

참가 물질

4

반응물 2

HCID 5209072-Butanamine, 3,3-dimethyl-HCID 100121892-Pyridinecarboximidic acid, N-cyano-, methyl ester

생성물 1

HCID 19734496N-cyano-N'-(1,2,2-trimethylpropyl)-2-pyridinecarboximidamide수율 93.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl N-cyano-2-pyridinecarboximidate (0.50 g, 3.1 mmol) was dissolved in methanol (10 ml), 1,2,2-trimethylpropylamine (0.34 g, 3.4 mmol) was added, and the resulting mixture was stirred at room temperature for 30 minutes. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the residue thus obtained was crystallized from dichloromethane-diethyl ether to give the title compound (0.67 g, 2.9 mmol, yield: 92%) as colorless needles.

후처리

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe residue thus obtained
  3. customwas crystallized from dichloromethane-diethyl ether

출처 및 근거

ORD 기록
ord-82e428b2221f4e3b85f487de96f59c23
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05223508

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