4-Methylbenzylamine → N-cyano-N'-(4-methylbenzyl)-3-pyridinecarboximidamide

HRID 1588522노트

반응식

HRID 1588522 반응식
[C:1]([N:3]=[C:4]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)OC(C)C)#[N:2].[CH3:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH2:21])=[CH:18][CH:17]=1>CO>[C:1]([NH:3][C:4]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)=[N:21][CH2:20][C:19]1[CH:22]=[CH:23][C:16]([CH3:15])=[CH:17][CH:18]=1)#[N:2]

참가 물질

4

반응물 2

HCID 660354-MethylbenzylamineHCID 100812013-Pyridinecarboximidic acid, N-cyano-, 1-methylethyl ester

생성물 1

HCID 19734558N-cyano-N'-(4-methylbenzyl)-3-pyridinecarboximidamide수율 92.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Isopropyl N-cyano-3-pyridinecarboximidate (0.50 g, 2.6 mmol) was dissolved in methanol (5 ml), and 4-methylbenzylamine (0.35 g, 2.9 mmol) was added. The mixture was stirred at room temperature for 30 minutes. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the concentrated residue thus obtained was crystallized from diethyl ether to give the title compound (0.60 g, 2.4 mmol, yield: 91%) as colorless powder.

후처리

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe concentrated residue thus obtained
  3. customwas crystallized from diethyl ether

출처 및 근거

ORD 기록
ord-b1755cd4cc1a48018ff67c6b1c315732
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05223508

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