Tetrabutylammonium Fluoride → alpha-Ethynylbenzenemethanol

HRID 1588718

반응식

HRID 1588718 반응식
C[Si]([C:5]#[C:6][CH:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[OH:8])(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[C:6]([CH:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[OH:8])#[CH:5]

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 27604161-Phenyl-3-(trimethylsilyl)-2-propyn-1-ol

생성물 1

HCID 20155alpha-Ethynylbenzenemethanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Place a mixture of α-[(trimethylsilyl)ethynyl]-benzene-methanol (1.87 g, 9.13mmol) and tetrahydrofuran (11 mL) under argon atmosphere. Add, by dropwise addition, tetra-n-butylammonium fluoride (11 mL of a 1M solution in tetrahydrofuran, 11 mmol). Stir for 1 hour at room temperature and partition between ethyl ether and water. Separate the organic phase, wash with saturated aqueous sodium chloride, dry (MgSO4), filter, and concentrate in vacuo to yield the title compound.

후처리

  1. custompartition between ethyl ether and water
  2. customSeparate the organic phase
  3. washwash with saturated aqueous sodium chloride
  4. dry with materialdry (MgSO4)
  5. filtrationfilter
  6. concentrationconcentrate in vacuo

출처 및 근거

ORD 기록
ord-3c830598d89149feb4735d7649e831d5
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05223518

연결된 노트

불러오는 중…