Ethanol → Ethyl 3-(difluoromethyl)-1-(2-propenyl)-1H-pyrazole-4-carboxylate

반응식

[OH-].[K+].[F:3][CH:4]([F:13])[C:5]1[C:9]([C:10]([OH:12])=[O:11])=[CH:8][NH:7][N:6]=1.[CH2:14](Br)[CH:15]=[CH2:16].[CH2:18](O)[CH3:19]>>[F:13][CH:4]([F:3])[C:5]1[C:9]([C:10]([O:12][CH2:18][CH3:19])=[O:11])=[CH:8][N:7]([CH2:14][CH:15]=[CH2:16])[N:6]=1

참가 물질

반응물 4

HCID 702Ethanol2회

HCID 7841Allyl bromide

HCID 14797Potassium Hydroxide

HCID 178524804HCID 178524804, 화합물

생성물 1

HCID 19754742Ethyl 3-(difluoromethyl)-1-(2-propenyl)-1H-pyrazole-4-carboxylate

실험 절차

To a solution of potassium hydroxide (3.5 g) in ethanol (50 mL) at 0° C. was added dropwise the ethyl ester of 3-(difluoromethyl)-1H-pyrazole-4-carboxylic acid (10.1 g) in ethanol (50 mL), followed by dropwise addition of allyl bromide (4.6 mL). The mixture was stirred overnight, partitioned between ether and 2N HCl. The ether layer was dried (MgSO4) and concentrated in vacuo leaving an oil (11.4 g). The oil was distilled (Kugelrohr 80-85 ° C., 0.3 mm) to give the isomer of the desired product as an oil (2.6 g). Distillation was continued (100-105 ° C., 0.3 mm) to give the desired compound as a clear colorless oil (8.0 g).