3-Cyclopropyl-3-(4-chlorophenyl)propan-1-ol → 3-Cyclopropyl-3-(4-chlorophenyl)propionaldehyde

HRID 1588877노트

반응식

HRID 1588877 반응식
[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[CH:12]1([CH:15]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[CH2:16][CH2:17][OH:18])[CH2:14][CH2:13]1>C(Cl)Cl.C(OCC)C>[CH:12]1([CH:15]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[CH2:16][CH:17]=[O:18])[CH2:14][CH2:13]1

참가 물질

5

반응물 2

HCID 197548323-Cyclopropyl-3-(4-chlorophenyl)propan-1-olHCID 178418287HCID 178418287, 화합물

생성물 1

HCID 197548433-Cyclopropyl-3-(4-chlorophenyl)propionaldehyde수율 24%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매2회

실험 절차

A mixture of 6.5 grams (0.03 mole) of pyridinium chlorochromate in 25 ml of methylene chloride was stirred, and a solution of 2.1 grams (0.03 mole) of 3-cyclopropyl-3-(4-chlorophenyl)propan-1-ol in 5 ml of methylene chloride was quickly added. Upon completion of addition, the reaction mixture was stirred at ambient temperature for one hour. The reaction mixture was then diluted with 100 ml of diethyl ether, and this mixture was filtered through a pad of activated magnesium silicate. The filtrate was concentrated under reduced pressure, yielding 1.5 grams of 3-cyclopropyl-3-(4-chlorophenyl)propionaldehyde.

후처리

  1. additionUpon completion of addition
  2. stirringthe reaction mixture was stirred at ambient temperature for one hour
  3. filtrationthis mixture was filtered through a pad of activated magnesium silicate
  4. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e7b8daec8f9d4998aad5ea326c1e59dc
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05223536

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