Dimethylformamide → 4-Formylbenzoic acid

HRID 1588919

반응식

HRID 1588919 반응식
S(Cl)(Cl)=[O:2].CN(C)[CH:7]=[O:8].[CH:10]1(NC2CCCC2)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.C1[CH2:26][O:25]CC1>C1C=CC=CC=1>[C:26]([C:10]1[CH:11]=[CH:12][C:13]([CH:7]=[O:8])=[CH:14][CH:15]=1)([OH:25])=[O:2]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 24386Thionyl ChlorideHCID 219797n-Cyclopentylcyclohexanamine

생성물 1

HCID 120884-Formylbenzoic acid

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

The acid chloride of 4-carboxybenzaldehyde (7.0 g, 46.5 mmol) was prepared in the same manner as in Example 29 using thionyl chloride (3.5 mL) and dimethylformamide (0.34 mL) in benzene (250 mL). The amide was prepared from the acid chloride in the same manner and using the same workup procedure as in Example 29 using N-cyclohexyl-N-cyclopentyl amine (15.6 g, 93.1 mmol) in THF (150 mL) at 0° C. The crude product was suitable for use without further purification.

후처리

  1. customat 0° C
  2. customThe crude product was suitable for use without further purification

출처 및 근거

ORD 기록
ord-a872729bfc2f4169ba1c28cdba5a239d
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05223539

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