Triethylamine → HCID 53933994, 화합물

HRID 1588924노트

반응식

HRID 1588924 반응식
[C:1]([NH:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.C1(N(C2CCCCC2)[C:25](=[O:34])[C:26]2[CH:31]=[CH:30][C:29]([Br:32])=[C:28](C)[CH:27]=2)CCCC1>C1COCC1>[C:1]([N:5]([CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]1)[C:25](=[O:34])[C:26]1[CH:31]=[CH:30][C:29]([Br:32])=[CH:28][CH:27]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 103920N-tert-ButylcyclohexylamineHCID 19754882HCID 19754882, 화합물

생성물 1

HCID 53933994HCID 53933994, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a cold (0° C. to 5° C.) stirred solution of N-tertbutyl-N-cyclohexyl amine (3.73 g, 24 mmol) and triethylamine (2.5 g, 24 mmol) in dry THF (50 mL) is added dropwise a solution of acid chloride (5.0 g, 23 mmol) in THF (20 mL). The reaction is stirred at room temperature overnight and worked up in the same manner as for 4-bromo-3-methylbenzoic acid N-cyclopentyl-N-cyclohexyl amide. The crude product is purified by either recrystallization or by chromatography on silica gel using mixtures of ethyl acetate and hexane as eluents.

후처리

  1. customThe crude product is purified by either recrystallization or by chromatography on silica gel using mixtures of ethyl acetate and hexane as eluents

출처 및 근거

ORD 기록
ord-215abfd26b2f4e69871890c1324462e1
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05223539

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