Benzoyl isothiocyanate → 5-(3-Benzoyl-thioureido)-1-methyl-1H-imidazole-4-carboxylic acid amide

HRID 1588942노트

반응식

HRID 1588942 반응식
[NH2:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]([NH2:10])=[O:9].[C:11]([N:19]=[C:20]=[S:21])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CC(C)=O>[C:11]([NH:19][C:20]([NH:1][C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]([NH2:10])=[O:9])=[S:21])(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 2

HCID 68284Benzoyl isothiocyanateHCID 64202875-Amino-1-methyl-1H-imidazole-4-carboxamide

생성물 1

HCID 148971415-(3-Benzoyl-thioureido)-1-methyl-1H-imidazole-4-carboxylic acid amide수율 95%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

5-Amino-1-methyl-1H-imidazole-4-carboxamide (6.5 g, 45 mM) and benzoylisothiocyanate (7.7 g, 47 mM) were refluxed in acetone (90 ml) for 4 hours under N2. After cooling in an ice bath the formed product was filtered off, washed with acetone and dried. Hereby was isolated 13.0 g (95%) of the title compound as a white powder, mp 194°-196° C.

후처리

  1. temperatureAfter cooling in an ice bath the formed product
  2. filtrationwas filtered off
  3. washwashed with acetone
  4. customdried

출처 및 근거

ORD 기록
ord-53af0f7e8d0f4d2bb913e64a8b8e1b3e
출처 데이터셋
uspto-grants-1993_06
특허 번호
US05223619

반응 노트

불러오는 중…