2,3-Dibromopropionamide → 4-(2-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide

반응식

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][CH2:10][CH2:11][NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.Br[CH:21]([CH2:25]Br)[C:22]([NH2:24])=[O:23]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:21]([C:22]([NH2:24])=[O:23])[CH2:25]1

참가 물질

반응물 2

HCID 857982,3-Dibromopropionamide

HCID 14998755N-(2-Methoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine

생성물 1

HCID 149987564-(2-Methoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide

실험 절차

In a manner similar to Preparation 1, react N-(2-methoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine (15.4 g, 60.2 mmol) with 2,3-dibromopropanamide (27.7 g, 0.12 mol) to give the title compound.

후처리

customIn a manner similar to Preparation 1

출처 및 근거

ORD 기록: ord-f674572a849944d5bc0e15bbfab7cf51
출처 데이터셋: uspto-grants-1993_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05223623

반응 노트

불러오는 중…