Hydrogen Peroxide → 4-(2-Hydroxyethoxy)phenol

HRID 1589120

반응식

HRID 1589120 반응식
CC([C:4]1[CH:13]=[CH:12][C:7]([O:8][CH2:9][CH2:10][OH:11])=[CH:6][CH:5]=1)=C.OO.[OH:16]S(O)(=O)=O.[O-]S([O-])=O.[Na+].[Na+]>CO>[OH:11][CH2:10][CH2:9][O:8][C:7]1[CH:12]=[CH:13][C:4]([OH:16])=[CH:5][CH:6]=1

참가 물질

6

반응물 4

HCID 784Hydrogen PeroxideHCID 1118Sulfuric AcidHCID 24437Sodium SulfiteHCID 137506132-(4-(1-Methylethenyl)phenoxy)ethanol

생성물 1

HCID 98340144-(2-Hydroxyethoxy)phenol

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a mixture of 2.50 g 2-(4-(1-methylethenyl)phenoxy)ethanol, 10 ml methanol, and 1.1 equivalents 50% aqueous H2O2 were added 0.1 equivalent 98% H2SO4. The reaction mixture warmed itself to reflux which subsided in a few minutes. After addition of 0.2 equivalent Na2SO3, methanol was removed under reduced pressure. The residue was taken up in ether, dried over Na2SO4 and NaHCO3, and filtered. Removal of solvent left 4-(2-(hydroxyethoxy)phenol in quantitative yield.

후처리

  1. temperatureThe reaction mixture warmed itself
  2. temperatureto reflux which
  3. waitsubsided in a few minutes
  4. customwas removed under reduced pressure
  5. dry with materialdried over Na2SO4 and NaHCO3
  6. filtrationfiltered
  7. customRemoval of solvent
  8. waitleft 4-(2-(hydroxyethoxy)phenol in quantitative yield

출처 및 근거

ORD 기록
ord-cec16df0b1c044d2bfff9ae1791d2268
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04568497

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