6-Fluoronicotinic Acid → 1-(6-Fluoropyridin-3-yl)ethan-1-one
반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:10])=O)=[CH:4][N:3]=1.[CH3:11][Li]>CCOCC>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[N:3][CH:4]=1)(=[O:10])[CH3:11]참가 물질
4
실험 절차
To suspension of 20 gm. (142 mmoles) of 2-fluoro-5-pyridinecarboxylic acid (J. Am. Chem. Soc., 71, 1125 (1949)) in 750 ml. of ether, stirred and cooled in ice, was added 225 ml. of 1.6M methyl lithium (360 mmoles) in ether over 1 hr. The reaction was stirred for an additional 2 hr., then 300 ml. of ice water was added. The aqueous layer was washed with 2×100 ml. fresh ether, acidified and extracted with ether to give 5.0 gm. (25%) of unreacted starting acid.
후처리
- additionTo suspension of 20 gm
- temperaturecooled in ice
- additionwas added 225 ml
- washThe aqueous layer was washed with 2×100 ml
- extractionextracted with ether
- customto give 5.0 gm
출처 및 근거
- ORD 기록
- ord-38b13558b83045acaf9e380a024e213e
- 출처 데이터셋
- uspto-grants-1986_02
- 특허 번호
- US04568679
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