Imidazole → 3-(1H-Imidazol-1-yl)-2-methylpropan-1-amine

반응식

[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[C:6](#[N:10])[C:7]([CH3:9])=[CH2:8]>>[N:1]1([CH2:8][CH:7]([CH3:9])[CH2:6][NH2:10])[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

반응물 2

HCID 795Imidazole

HCID 31368Methacrylonitrile

생성물 1

HCID 139528593-(1H-Imidazol-1-yl)-2-methylpropan-1-amine

실험 절차

A mixture of 15.0 g. of imidazole and 25 ml. of methacrylonitrile was heated at reflux temperature for 18 hours and then concentrated to remove the volatile material. The residue was mixed with 150 ml. of ethanol, 75 ml. of ammonium hydroxide and 6 g. of Raney Nickel catalyst and reduced in a Parr hydrogenator under hydrogen pressure until reduction was complete. The catalyst was removed by filtration and the mother liquor was concentrated to remove the solvents. The residual oil was used in reactions without further purification.

후처리

additionA mixture of 15.0 g
temperatureat reflux temperature for 18 hours
concentrationconcentrated
customto remove the volatile material
additionThe residue was mixed with 150 ml
customThe catalyst was removed by filtration
concentrationthe mother liquor was concentrated
customto remove the solvents
customThe residual oil was used in reactions without further purification

출처 및 근거

ORD 기록: ord-8a5cb7a754324781a6438db3b65fd06d
출처 데이터셋: uspto-grants-1986_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04568687

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