4-(2-Methoxy-4-methylmercapto-benzoylamino)-5-nitro-1H-pyridin-2-one → 2-(2-Methoxy-4-methylmercapto-phenyl)-5H-imidazo[4,5-c]-pyridin-6-one

HRID 1589296노트

반응식

HRID 1589296 반응식
[CH3:1][O:2][C:3]1[CH:21]=[C:20]([S:22][CH3:23])[CH:19]=[CH:18][C:4]=1[C:5]([NH:7][C:8]1[C:13]([N+:14]([O-])=O)=[CH:12][NH:11][C:10](=[O:17])[CH:9]=1)=O>C(O)(=O)C.[Fe]>[CH3:1][O:2][C:3]1[CH:21]=[C:20]([S:22][CH3:23])[CH:19]=[CH:18][C:4]=1[C:5]1[N:14]=[C:13]2[CH2:12][NH:11][C:10](=[O:17])[CH:9]=[C:8]2[N:7]=1

참가 물질

4

반응물 1

HCID 135209344-(2-Methoxy-4-methylmercapto-benzoylamino)-5-nitro-1H-pyridin-2-one

생성물 1

HCID 704558092-(2-Methoxy-4-methylmercapto-phenyl)-5H-imidazo[4,5-c]-pyridin-6-one

시약·촉매·용매 2

HCID 23925Iron촉매HCID 176Acetic Acid용매

실험 절차

0.6 g of crude 4-(2-methoxy-4-methylmercapto-benzoylamino)-5-nitro-1H-pyridin-2-one were dissolved in 10 ml of glacial acetic acid, the solution was mixed with two spatula tipsful of iron powder, and the mixture was stirred for 30 minutes at room temperature. The mixture was then refluxed for 20 minutes, filtered, and the filtrate was evaporated in vacuo. The product thus obtained were purified by chromatography on silica gel (eluant: methylene chloride/ethanol=100:2 to 100:15).

후처리

  1. temperatureThe mixture was then refluxed for 20 minutes
  2. filtrationfiltered
  3. customthe filtrate was evaporated in vacuo
  4. customThe product thus obtained
  5. customwere purified by chromatography on silica gel (eluant: methylene chloride/ethanol=100:2 to 100:15)

출처 및 근거

ORD 기록
ord-18630330845a4e4cb0b76e3da355b2ef
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04568680

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