Ammonia → HCID 70455630, 화합물

HRID 1589297노트

반응식

HRID 1589297 반응식
Cl.C[O:3][C:4]1[C:9]([NH2:10])=[C:8]([NH2:11])[CH:7]=[CH:6][N:5]=1.[CH3:12][O:13][C:14]1[CH:22]=[C:21]([S:23][CH3:24])[CH:20]=[CH:19][C:15]=1[C:16](Cl)=O.N>O>[CH3:12][O:13][C:14]1[CH:22]=[C:21]([S:23][CH3:24])[CH:20]=[CH:19][C:15]=1[C:16]1[N:10]=[C:9]2[C:4](=[O:3])[NH:5][CH2:6][CH:7]=[C:8]2[N:11]=1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 27595912-Methoxy-4-(methylthio)benzoyl chlorideHCID 202482542-Methoxy-3,4-diamino-pyridine hydrochloride

생성물 1

HCID 70455630HCID 70455630, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

0.88 g of 2-methoxy-3,4-diamino-pyridine hydrochloride and 1.08 g of 2-methoxy-4-methylmercapto-benzoyl chloride were intimately mixed, and the mixture was stirred into warm polyphosphoric acid at 120° C. The mixture was kept at this temperature for an hour and was then poured into water, the aqueous mixture was made alkaline with ammonia, and the precipitate thus obtained was purified on a silica gel column (eluant: methylene chloride/methanol=100:10).

후처리

  1. waitThe mixture was kept at this temperature for an hour
  2. customthe precipitate thus obtained
  3. customwas purified on a silica gel column (eluant: methylene chloride/methanol=100:10)

출처 및 근거

ORD 기록
ord-8eb90bdb6e014f0b9d71834aa967875a
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04568680

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