Fumarate → bromomesaconic acid

HRID 1589333노트

반응식

HRID 1589333 반응식
[Br:1][CH2:2]/[C:3](=[CH:7]/[C:8]([OH:10])=[O:9])/[C:4]([OH:6])=[O:5].C([O-])(=O)/C=C/C([O-])=O.BrCC1C(OC(=O)C=1)=O>>[Br:1][CH2:2]/[C:3](=[CH:7]\[C:8]([OH:10])=[O:9])/[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 3

HCID 5460307FumarateHCID 109870762,5-Furandione, 3-(bromomethyl)-HCID 86740308HCID 86740308, 화합물2회

생성물 1

HCID 6449799bromomesaconic acid

실험 절차

Steps are taken to avoid isomerization of 2-(bromomethyl)-maleic acid (3) to the corresponding fumarate analog by hydrolyzing the anhydride (2) in a dilute aqueous solution and neutralizing the diacid (3) immediately after complete hydrolysis. Any bromomethyl fumaric acid derivative formed is removed in purifying compound (4) as described in more detail below.

후처리

  1. customimmediately after complete hydrolysis

출처 및 근거

ORD 기록
ord-175c0a18416848a2975bcd98424f1b90
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04569789

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