참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Magnesium orthosilicate | HCID 66225 | — |
| 반응물 | 3-Chloro-6-[3-(trifluoromethyl)phenyl]pyridazine | HCID 12449552 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-Methyl-6-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazine | HCID 13565362 | 28.8% |
반응 단계
A mixture of 5.18 g of 3-chloro-6-[3-(trifluoromethyl)phenyl]pyridazine and 4.60 g of aminoacetoneethyleneketal was heated at 150° C. under argon for 4 hours. The cooled mixture was dissolved in dichloromethane and the solution passed through a short pad of hydrous magnesium silicate. The filtrate was concentrated, diluted with hexane and chilled to give 0.8 g of crystals, mp 98°-100° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04569934 |
|---|
| 출처 데이터셋 | uspto-grants-1986_02 |
|---|
| ORD ID | ord-2e9c1a9597994fd2a9b681da0e39e9b5 |
|---|
| 출처 메모 | uspto-grants-1986_02 |
|---|
