Ammonia → 3-Amino-6-(3-trifluoromethylphenyl)pyridazine

HRID 1589466

반응식

HRID 1589466 반응식
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)=[CH:6][CH:7]=1.[NH3:18]>>[NH2:18][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 222Ammonia2회HCID 124495523-Chloro-6-[3-(trifluoromethyl)phenyl]pyridazine

생성물 1

HCID 135653673-Amino-6-(3-trifluoromethylphenyl)pyridazine

반응 조건

온도
200 °C

실험 절차

A 12.5 g sample of 3-chloro-6-[3-(trifluoromethyl)phenyl]pyridazine was placed in a steel cylinder with liquid ammonia and the sealed cylinder (bomb) was heated at 200° C. The chilled cylinder was opened and the ammonia allowed to evaporate. The solid residue was heated and stirred with chloroform, then filtered. The filtrate was concentrated and the residue recrystallized, first from chloroform-hexane, then twice from chloroform to give 1.8 g of 3-amino-6-[3-(trifluoromethyl)phenyl]pyridazine as white crystals, mp 143°-145° C.

후처리

  1. customto evaporate
  2. temperatureThe solid residue was heated
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated
  5. customthe residue recrystallized, first from chloroform-hexane

출처 및 근거

ORD 기록
ord-249344310eed46bab2a8f1c73e2d6122
출처 데이터셋
uspto-grants-1986_02
특허 번호
US04569934

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