Water → HCID 178447875, 화합물

HRID 1589742노트

반응식

HRID 1589742 반응식
[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([C:10]2[CH:18]=[CH:17][C:13]([CH2:14][C:15]#N)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)[CH2:2][CH3:3].[OH2:19].[OH-:20].[K+]>CO>[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([C:10]2[CH:18]=[CH:17][C:13]([CH2:14][C:15]([OH:20])=[O:19])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)[CH2:2][CH3:3]

참가 물질

5

반응물 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 178447873HCID 178447873, 화합물

생성물 1

HCID 178447875HCID 178447875, 화합물수율 97.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

106 g (0.44 mol) of 4-(trans-4'-propylcyclohexyl) benzyl cyanide, 40 g of water, 145 g (2.2 mol) of KOH and 440 cm3 of methanol were refluxed for 10 hours using a mantle heater. The ethanol was distilled off under reduced pressure. The residue was dissolved in 300 cm3 of water and poured into 300 cm3 of concentrated hydrochloric acid and 300 g of ice. The crystals deposited were filtered out and washed with cold water. The crystals were recrystallized from methanol to yield 112 g (0.43 mol) of 4-(trans-4'-propylcyclohexyl)phenyl acetic acid.

후처리

  1. distillationThe ethanol was distilled off under reduced pressure
  2. dissolutionThe residue was dissolved in 300 cm3 of water
  3. additionpoured into 300 cm3 of concentrated hydrochloric acid and 300 g of ice
  4. filtrationThe crystals deposited were filtered out
  5. washwashed with cold water
  6. customThe crystals were recrystallized from methanol

출처 및 근거

ORD 기록
ord-af198656fdec4b6d8e75434dfa446362
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05200110

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