Ammonia → 4-Bromo-3,5-difluorobenzimidamide Hydrochloride
반응식
[NH3:1].[ClH:2].[Br:3][C:4]1[C:12]([F:13])=[CH:11][C:7]([C:8](=[NH:10])O)=[CH:6][C:5]=1[F:14]>C(O)C>[ClH:2].[Br:3][C:4]1[C:12]([F:13])=[CH:11][C:7]([C:8]([NH2:1])=[NH:10])=[CH:6][C:5]=1[F:14]참가 물질
4
실험 절차
450 cm3 of anhydrous ethanol saturated with dried gaseous ammonia was added to 4-bromo-3,5-difluorobenzimidate hydrogen chloride and stirred overnight at room temperature. About one-half of the volume of the solvent was distilled off and the residue was recrystallized to yield 90 g (0.36 mol) of 4-bromo-3,5-difluorobenzamidine hydrogen chloride.
후처리
- distillationAbout one-half of the volume of the solvent was distilled off
- customthe residue was recrystallized
출처 및 근거
- ORD 기록
- ord-f6eec6f26b3e4653a55336994f5e4806
- 출처 데이터셋
- uspto-grants-1993_04
- 특허 번호
- US05200110
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