Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dexamethasone → Cortisol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dexamethasone | HCID 5743 | — |
| 반응물 | Cortisol | HCID 5754 | — |
| 반응물 | Prednisolone | HCID 5755 | — |
| 반응물 | Perchloric Acid | HCID 24247 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Cortisol | HCID 5754 | — |
| 생성물 | Methyl 2-formylbutanoate | HCID 15570303 | — |
반응 단계
Hydrocortisone or prednisolone or dexamethasone or bethamethasone is reacted with an alkyl formylalkanoate in a solution of dichloromethane in the presence of catalytic amount of perchloric acid to produce the corresponding 17,21-carboxycyclic acetal pregnane derivatives, e.g., when hydrocortisone and methyl formylbutyrate are used the product is (IV) 11β-hydroxy-3,20-dioxo-17,21-(methoxycarbonyl-n-propyl) methylenedioxy-4-pregnene; when prednisolone and methyl formylacetate are used the product is (V) 11β-hydroxy-3,20-dioxo-17,21-(methoxycarbonylmethyl)methylenedioxy-1,4-pregnadiene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05200518 |
| 출처 데이터셋 | uspto-grants-1993_04 |
| ORD ID | ord-24c5eaea82c048f8aa221ac72203ad67 |
| 출처 메모 | uspto-grants-1993_04 |