Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cortisol → Butanoic acid, 2-ethyl-3-oxo-, methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cortisol | HCID 5754 | — |
| 반응물 | Prednisolone | HCID 5755 | — |
| 반응물 | Perchloric Acid | HCID 24247 | — |
| 반응물 | 11beta,17,20beta,21-Tetrahydroxypregna-1,4-dien-3-one 21-Acetate | HCID 13962388 | — |
| 생성물 | Butanoic acid, 2-ethyl-3-oxo-, methyl ester | HCID 103534 | — |
반응 단계
Hydrocortisone or prednisolone with 20-hydroxy and 21-acetoxy groups are known, e.g., (I) (20R)-21-acetoxy-11β, 17,20-trihydroxy-3-oxo-1,4-pregnadiene; and (I) is reacted with an alkyl acetylalkanoate in the presence of perchloric acid to produce the corresponding 17,20-carboxycyclic acetal pregnane derivatives, e.g., when methyl acetylbutyrate is used the product is (II) (20R)-21-acetoxy-11β-hydroxy-3-oxo-17,20-(methyl,methoxycarbonyl-n-propyl)methylenedioxy-1,4-pregnadiene;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05200518 |
| 출처 데이터셋 | uspto-grants-1993_04 |
| ORD ID | ord-8ef4d1660fef44e1bc2033b1081f7dac |
| 출처 메모 | uspto-grants-1993_04 |