Aniline → HCID 15022346, 화합물

HRID 1589986노트

반응식

HRID 1589986 반응식
[Cl:1][C:2]1[C:3]([C:7](Cl)=[O:8])=[CH:4][S:5][CH:6]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O1CCOCC1.N1C=CC=CC=1>[Cl:1][C:2]1[C:3]([C:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:8])=[CH:4][S:5][CH:6]=1

참가 물질

5

반응물 2

HCID 6115AnilineHCID 129147964-Chlorothiophene-3-carbonyl chloride

생성물 1

HCID 15022346HCID 15022346, 화합물

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 312751,4-Dioxane용매

실험 절차

At room temperature, a solution of 4-chlorothiophene-3-carboxylic chloride (13.5 g, 0.075 mol) in 30 ml of dioxane is dripped into a solution of aniline (7.7 g, 0.083 mol) in pyridine (160 ml). The mixture is stirred for 12 hours at room temperature and concentrated to dryness, and the residue is taken up in dichloromethane. The organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water, dried and concentrated to dryness. Yield: 16.7 g, 94%; m.p. 119°-121° C.

후처리

  1. customAt room temperature
  2. concentrationconcentrated to dryness
  3. extractionThe organic phase is extracted with aqueous citric acid solution, sodium bicarbonate solution and water
  4. customdried
  5. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-91cd8de8eaff4b6d88abbb93493c924c
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05201934

반응 노트

불러오는 중…