Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → 3-[[2-(Methoxymethyl)-1-pyrrolidinyl]imino]-1-phenyl-2-pyrrolidinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 2-(Methoxymethyl)pyrrolidin-1-amine | HCID 143663 | — |
| 반응물 | 1-Phenylpyrrolidine-2,3-dione | HCID 19023571 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 3-[[2-(Methoxymethyl)-1-pyrrolidinyl]imino]-1-phenyl-2-pyrrolidinone | HCID 57153373 | — |
반응 단계
A solution of the product of Example 61 and chiral 1-amino-2-methoxymethylpyrrolidine (SAMP or RAMP; 1 equiv) in benzene is refluxed under Dean-Stark conditions for 20 h After cooling, Et2O is added and the mixture is washed with water. The organic layer is dried (MgO4), and evaporated to give a residue which is chromatographed on silica gel to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05202344 |
| 출처 데이터셋 | uspto-grants-1993_04 |
| ORD ID | ord-4025d25706be4a47bd53045e959c41ba |
| 출처 메모 | uspto-grants-1993_04 |