Dimethyl Sulfoxide → 2,6-Dichloropyridine-4-carbaldehyde

HRID 1590392

반응식

HRID 1590392 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[C:4]([Cl:10])[N:3]=1.C(Cl)(=O)C(Cl)=O.CS(C)=O>C(N(CC)CC)C>[Cl:1][C:2]1[CH:7]=[C:6]([CH:8]=[O:9])[CH:5]=[C:4]([Cl:10])[N:3]=1

참가 물질

5

반응물 3

HCID 679Dimethyl SulfoxideHCID 65578Oxalyl chlorideHCID 2794840(2,6-Dichloropyridin-4-yl)methanol

생성물 1

HCID 27610242,6-Dichloropyridine-4-carbaldehyde수율 101.1%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

Oxidation of the above alcohol (1.2 g) according to the conditions of Swern (oxalyl chloride, 0.33 ml; dimethyl sulphoxide, 0.54 ml; triethylamine, 2.35 ml) gave (2,6-dichloro-4-pyridyl)methanal (1.2 g). NMR 1H: 10.02(1H,s), 7.68(2H,s).

출처 및 근거

ORD 기록
ord-f0cf90c7d95b416782c027e4531301dd
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05202356

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