4-(1,1,4-Trimethylpentyl)phenylethyne → 4-(1,1,4-Trimethylpentyl)bromobenzene

HRID 1590416

반응식

HRID 1590416 반응식
[CH3:1][C:2]([C:9]1[CH:14]=[CH:13][C:12](C#C)=[CH:11][CH:10]=1)([CH3:8])[CH2:3][CH2:4][CH:5]([CH3:7])[CH3:6].O=C(C1C=CC([Br:30])=CC=1)CCC(C)C.C[Al](C)C>CCCCCC>[CH3:1][C:2]([C:9]1[CH:14]=[CH:13][C:12]([Br:30])=[CH:11][CH:10]=1)([CH3:8])[CH2:3][CH2:4][CH:5]([CH3:7])[CH3:6]

참가 물질

5

반응물 3

HCID 149896684-(1,1,4-Trimethylpentyl)phenylethyne2회HCID 16682925TrimethylaluminumHCID 224090794-(1-Oxo-4-methyl-pentyl) bromobenzene2회

생성물 1

HCID 224090834-(1,1,4-Trimethylpentyl)bromobenzene

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

Reaction Scheme 6 discloses specific synthetic steps leading to 4-(1,1,4-trimethylpentyl)phenylethyne (Compound 34). In this synthetic route 4-(1-oxo-4-methyl-pentyl) bromobenzene (Compound 31, obtained for example as shown in Reaction Scheme 5) is reacted under a protective nitrogen atmosphere with trimethylaluminum in hexane to yield 4-(1,1,4-trimethyl-pentyl)bromobenzene (Compound 35). The bromobenzene derivative 35 is converted through the corresponding trimethylsilylethyne derivative 36 into the target intermediate 34 by treatment with trimethylsilyl ethyne and subsequently with KOH in isopropanol, as described above. ##STR10##

후처리

  1. customReaction Scheme 6

출처 및 근거

ORD 기록
ord-dd1c397b01ec49dd9c16149a92b91ea6
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05202471

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