Potassium Carbonate → HCID 178442094, 화합물

HRID 1590545

반응식

HRID 1590545 반응식
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([F:19])[C:13]=2[F:20])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[CH2:21]([C@H:26]1[CH2:31][CH2:30][C@H:29]([CH2:32]I)[CH2:28][CH2:27]1)[CH2:22][CH2:23][CH2:24][CH3:25].C([O-])([O-])=O.[K+].[K+]>CN(C)C=O>[CH2:1]([C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:32][C@H:29]3[CH2:30][CH2:31][C@H:26]([CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH2:27][CH2:28]3)=[C:14]([F:19])[C:13]=2[F:20])=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 191036434'-Pentyl-2,3-difluorobiphenyl-4-olHCID 178444521HCID 178444521, 화합물

생성물 1

HCID 178442094HCID 178442094, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

0.1 mol of 4'-n-pentyl-2,3-difluorobiphenyl-4-ol and 0.1 mol of trans-4-n-pentylcyclohexylmethyl iodide are heated to a gentle boil in the presence of 0.12 mol of anhydrous K2CO3 in dimethylformamide (DMF). When the reaction is complete, the mixture is worked up in the customary manner and the product is purified by chromatography and crystallization. Trans-4-n-pentylcyclohexylmethyl 4'-pentyl-2,3-difluorobiphenyl-4-yl ether, C (58° SC) 30° SA 72° N 116° I is obtained.

후처리

  1. customthe product is purified by chromatography and crystallization

출처 및 근거

ORD 기록
ord-43be758c72564cbdbc9d6a0752202bb7
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05204019

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