2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine → 4-(6-Methylimidazo[1,2-a]pyridin-2-yl)benzonitrile

HRID 1590616노트

반응식

HRID 1590616 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][C:14](Br)=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1.[C:18]([Cu])#[N:19].C(N)CN.O>CN(C=O)C>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([C:18]#[N:19])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1

참가 물질

5

반응물 3

HCID 8378932-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridineHCID 12200817Ethylenediamine monohydrateHCID 178418546HCID 178418546, 화합물

생성물 1

HCID 7359124-(6-Methylimidazo[1,2-a]pyridin-2-yl)benzonitrile

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

6-Methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine (6.0 g) was mixed with 3.0 g of CuCN and 50 ml DMF. The mixture was refluxed for 24 hrs. The hot solution was then poured into a (1:4) ethylenediamine-water mixture (200 ml). Using chloroform, the compound was extracted. The chloroform layer was washed with water, dried and evaporated. The residue was crystallized and recrystallized from ethanol; yield; 3.4 g (69%); mp 225°-226° C.

후처리

  1. temperatureThe mixture was refluxed for 24 hrs
  2. extractionUsing chloroform, the compound was extracted
  3. washThe chloroform layer was washed with water
  4. customdried
  5. customevaporated
  6. customThe residue was crystallized
  7. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-f3a59b841d974501bf7bbc78456eb120
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05204352

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