Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (RS)-Clopidogrel
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Methyl [2-(2-thienyl)ethylamino](2-chlorophenyl)acetate | HCID 10223136 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (RS)-Clopidogrel | HCID 2806 | — |
반응 단계
35 g of the hydrochloride of racemic methyl alpha-(2-thienylethylamino)(2-chlorophenyl)acetate are suspended in 150 ml of a 30% (w/w) aqueous solution of formaldehyde. The mixture is kept at 50° C. for 2 hours and then poured, at about 20° C., into 200 ml of methylene chloride. The organic phase is concentrated and the residual oil is dissolved in 120 ml of isopropyl ether in which the hydrochloride is prepared as before; 29.5 g are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05204469 |
| 출처 데이터셋 | uspto-grants-1993_04 |
| ORD ID | ord-f5c9992b4803468f97c3f790d71a0507 |
| 출처 메모 | uspto-grants-1993_04 |