Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl lactate → 2-(4-Octyloxy-2-fluorophenyl)-5-(1-cyanoethoxy)-pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl lactate | HCID 98054 | — |
| 반응물 | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| 반응물 | 2-(4-Octyloxy-2-fluorophenyl)-5-hydroxypyridine | HCID 22717460 | — |
| 생성물 | 2-(4-Octyloxy-2-fluorophenyl)-5-(1-cyanoethoxy)-pyridine | HCID 19768414 | — |
반응 단계
Optically active benzyl lactate is etherified by means of diethyl azodicarboxylate (DEAD)/triphenylphosphine with 2-(4-octyloxy-2-fluorophenyl)-5-hydroxypyridine (prepared in accordance with Example 1) and the benzyl group is then split off hydrogenolytically. The acid so obtained is converted as usual into the nitrile (oxalyl chloride, ammonia, thionyl chloride). Optically active 2-(4-octyloxy-2-fluorophenyl)-5-(1-cyanoethoxy)-pyridine is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05204476 |
| 출처 데이터셋 | uspto-grants-1993_04 |
| ORD ID | ord-c13875652fd042b99e09cb22bf04964e |
| 출처 메모 | uspto-grants-1993_04 |