Triethylamine → HCID 131717864, 화합물

HRID 1590962노트

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HRID 1590962 반응식
[NH2:1][C@H:2]([C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[OH:6].C(N(CC)CC)C.[NH:25]([C:47]([O:49][C:50]([CH3:53])([CH3:52])[CH3:51])=[O:48])[C@H:26]([C:37]([O:39]N1C(=O)CCC1=O)=[O:38])[C@@H:27]([CH3:36])[O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>C(#N)C>[CH3:36][C@@H:27]([O:28][CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)[C@H:26]([NH:25][C:47]([O:49][C:50]([CH3:52])([CH3:53])[CH3:51])=[O:48])[C:37]([OH:39])=[O:38].[NH2:1][C@H:2]([C:8]([O:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9])[CH2:3][CH2:4][C:5](=[O:6])[OH:7]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 7009632(4S)-4-amino-5-benzyloxy-5-oxo-pentanoic acidHCID 12879029Boc-Thr(Bzl)-OSu

생성물 1

HCID 131717864HCID 131717864, 화합물수율 87.2%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of 2.83 g of H-Glu-OBzl dissolved in 40 ml of acetonitrile were added 3.3 ml of triethylamine and 5.00 g of Boc-Thr(Bzl)-OSu under ice-cooling. The mixture was stirred overnight at room temperature. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in 50 ml of ethyl acetate and the resulting solution was washed with 30 ml of water twice. The ethyl acetate layer was dried with anhydrous magnesium sulfate. The solvent was removed by distillation to dry the ethyl acetate layer, whereby 5.50 g (yield: 87.2%) of the above objective compound was obtained as a powder form product.

후처리

  1. temperaturecooling
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. dissolutionThe residue was dissolved in 50 ml of ethyl acetate
  4. washthe resulting solution was washed with 30 ml of water twice
  5. dry with materialThe ethyl acetate layer was dried with anhydrous magnesium sulfate
  6. customThe solvent was removed by distillation
  7. dry with materialto dry the ethyl acetate layer

출처 및 근거

ORD 기록
ord-0c5d9703500a43a5b5b338648344c05e
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05204326

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