N-(tert-butoxycarbonyl)glycine → Boc-Gly-Ala-Ser(Bzl)-Leu-OEt

HRID 1590990노트

반응식

HRID 1590990 반응식
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:4]([NH:6][C@H:7]([C:17]([NH:19][C@H:20]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:21][CH:22]([CH3:24])[CH3:23])=[O:18])[CH2:8][O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:5])[CH3:3].[NH:37]([C:42]([O:44][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:43])[CH2:38][C:39]([OH:41])=O>>[NH:37]([C:42]([O:44][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:43])[CH2:38][C:39]([NH:1][C@H:2]([C:4]([NH:6][C@H:7]([C:17]([NH:19][C@H:20]([C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:21][CH:22]([CH3:24])[CH3:23])=[O:18])[CH2:8][O:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:5])[CH3:3])=[O:41]

참가 물질

3

반응물 2

HCID 78288N-(tert-butoxycarbonyl)glycineHCID 131717876Boc-Ala-Ser(Bzl)-Leu-OEt

생성물 1

HCID 131717877Boc-Gly-Ala-Ser(Bzl)-Leu-OEt수율 77.8%

실험 절차

By using 3.50 g of Boc-Ala-Ser(Bzl)-Leu-OEt and 1.30 g of Boc-Gly-OH, and the same procedure as in Reference Example 15 was repeated to obtain 3.03 g (yield: 77.8%) of the above-mentioned objective product.

출처 및 근거

ORD 기록
ord-401ba622147140c0bb8d96baf0a41c8b
출처 데이터셋
uspto-grants-1993_04
특허 번호
US05204326

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